Biodegradable polyol-based polymers for biomedical applications

Dasgupta, Queeny and Madras, Giridhar and Chatterjee, Kaushik (2019) Biodegradable polyol-based polymers for biomedical applications. In: INTERNATIONAL MATERIALS REVIEWS, 64 (5). pp. 288-309.

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Abstract

Polyols are multifunctional alcohols, with branched structures, where each arm terminates with an -OH group. These free -OH groups have been utilised to make a variety of polymer structures ranging from cross-linked to linear to starshaped. This review presents a comprehensive account of polyol-based polymers in biomedical applications. The advantages afforded by polyolbased biodegradable polymers are detailed in this review, alongside a general historical perspective on the development of biodegradable polymers. The major advantage of these polyols is that they are endogenous to the human body. Synthesis strategies and fabrication techniques to mould these materials into three-dimensional (3D) scaffolds are discussed. Modifications to the conventionally used polyol-based polyesters have been achieved by chemically incorporating drugs/ bioactives or by preparing nanocomposites. This review discusses the physicochemical properties and biological responses of these polymers relevant in biomedical applications and further outlines the need for improving their processability and performance.

Item Type:	Journal Article
Publication:	INTERNATIONAL MATERIALS REVIEWS
Publisher:	TAYLOR & FRANCIS LTD
Additional Information:	Copyright of this article belongs to Taylor & Francis
Keywords:	Polyols; xylitol; biodegradable polymers; biomaterials; tissue engineering; drug delivery
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering Division of Mechanical Sciences > Chemical Engineering Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	20 May 2019 09:15
Last Modified:	21 May 2019 05:38
URI:	http://eprints.iisc.ac.in/id/eprint/62355

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