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Chitosan-Glycerol Gel as Barrier Formulation for Metal Allergy

Ramesan, VS and Jain, S (2019) Chitosan-Glycerol Gel as Barrier Formulation for Metal Allergy. In: ACS Omega, 4 (3). pp. 5900-5903.

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Official URL: https://doi.org/10.1021/acsomega.9b00326


Metal-induced allergic contact dermatitis, particularly nickel, affects over 10 of the general population. Herein, chitosan-glycerol gel as protective barrier formulation was synthesized by neutralization reaction with an aim to reduce metal-ion diffusion into the skin to prevent allergy. Active functional groups in chitosan-glycerol gel were able to capture allergenic metal ions present in artificial sweat solution. The efficacy of the barrier formulation against nickel-ion penetration was evaluated ex vivo using pig skin. We found that the percutaneous absorption of nickel ion reduced by 98 when chitosan-glycerol gel was used as a barrier formulation. © Copyright © 2019 American Chemical Society.

Item Type: Journal Article
Publication: ACS Omega
Publisher: ACS Publications
Additional Information: Copyright for this article belongs to ACS Publications.
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 06 May 2019 17:26
Last Modified: 06 May 2019 17:26
URI: http://eprints.iisc.ac.in/id/eprint/62216

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