Singh, N and Savanur, MA and Srivastava, S and D'Silva, P and Mugesh, G (2019) A manganese oxide nanozyme prevents the oxidative damage of biomolecules without affecting the endogenous antioxidant system. In: Nanoscale, 11 (9). pp. 3958-3967.
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Abstract
Biocompatible nanoparticles with an intrinsic ability to mimic the cellular antioxidant enzymes are potential candidates for the development of new therapeutics for various oxidative stress related disorders. However, the understanding of the interaction and the mechanistic crosstalk between the nanoparticles and the cellular biomolecules is limited. Here we show that the multienzyme mimic manganese(ii,iii) oxide, Mn 3 O 4 , in nanoform (Mp) rescues the cells from oxidative damage induced by reactive oxygen species (ROS). The nanoparticles provide remarkable protection to biomolecules against the ROS-mediated protein oxidation, lipid peroxidation and DNA damage. Interestingly, the endogenous antioxidant machinery remains unaltered in the presence of these nanozymes, indicating the small molecule targeting of these nanoparticles in the cellular redox modulation. This study delineates the possible mechanism by which the nanoparticles provide protection to the cells against the adverse effects of oxidative stress. Based on our observation, we suggest that the multienzyme mimic Mn 3 O 4 nanoparticles possess great potential in suppressing the oxidative stress-mediated pathophysiological conditions under which the antioxidant system is overwhelmed. This journal is © The Royal Society of Chemistry.
Item Type: | Journal Article |
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Publication: | Nanoscale |
Publisher: | Royal Society of Chemistry |
Additional Information: | copyright for this article belongs to Royal Society of Chemistry |
Keywords: | Antioxidants; Biocompatibility; Machinery; Manganese oxide; Nanoparticles; Oxidative stress, Antioxidant enzyme; Antioxidant systems; Biocompatible nanoparticles; Lipid peroxidation; Oxidative stress-related disorders; Pathophysiological; Possible mechanisms; Reactive oxygen species, Biomolecules |
Department/Centre: | Division of Biological Sciences > Biochemistry Division of Chemical Sciences > Inorganic & Physical Chemistry Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering |
Date Deposited: | 08 Apr 2019 11:18 |
Last Modified: | 08 Apr 2019 11:18 |
URI: | http://eprints.iisc.ac.in/id/eprint/61999 |
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