ROS dependent antitumour activity of photo-activated iron(III) complexes of amino acids

Chanu, Binita S and Raza, Md Kausar and Banerjee, Samya and Mina, Pooja Rani and Musib, Dulal and Roy, Mithun (2019) ROS dependent antitumour activity of photo-activated iron(III) complexes of amino acids. In: JOURNAL OF CHEMICAL SCIENCES, 131 (2).

	PDF Jou_Che_Sci_131-2_2019.pdf - Erratum / Correction(s) Restricted to Registered users only Download (271kB) | Request a copy
Preview	PDF ROS dependent antitumour activity of photo-activated iron(III).pdf Download (1MB) | Preview

Abstract

Several amino acid-based photo-active monomeric iron(III) complexes of the general formula, [Fe(L)2]-, where L = Schiff base ligands (salisalidene arginine, salicylidenetryptophan, 3,5-di-tert-butyl benzalidine arginine and salicylidene tryptophan) were synthesized, characterized and explored for photo-activated anticancer activity to Chang Liver Cells, HeLa and MCF-7 cells. Complexes exhibited remarkable photo-cytotoxicity with IC 50 value to the extent of 0.7μM to Chang Liver Cells in visible light and there was a 40-fold enhancement in cytotoxicity in comparison to the cytotoxicity in dark. Complexes were non-toxic to MCF-10A (normal cells) in dark and visible light (IC50>100μM in dark; IC50>80μM in visible light) signifying target-specific nature of the anti-tumour activity of the complexes. Increased ROS concentration, as probed by DCFDA assay, in the cancer cells was responsible for apoptotic cell death. Decarboxylation or phenolate-Fe(III) charge transfer of photo-activated iron(III) complexes generating ∙OH radicals (ROS) were responsible for the apoptosis. Overall, the tumour-selective photo-activated anticancer activity of the amino acid-based iron(III) complexes have shown a promising aspect in developing iron-based photo-chemotherapeutics as the next generation PDT agents. Graphical abstract: Monomeric iron(III) complexes are explored for photo-activated antitumour activity. Photodecarboxylation or photo-induced charge transfer of phenolate-O → Fe(III) has led to the generation of hydroxyl radicals causing apoptotic cell death.

Item Type:	Journal Article
Publication:	JOURNAL OF CHEMICAL SCIENCES
Publisher:	INDIAN ACAD SCIENCES
Additional Information:	Copyright of this article belongs to SPRINGER
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	26 Feb 2019 05:05
Last Modified:	23 Sep 2022 05:50
URI:	https://eprints.iisc.ac.in/id/eprint/61826

Actions (login required)

View Item