Egocentric coding of external items in the lateral entorhinal cortex

Wang, Cheng and Chen, Xiaojing and Lee, Heekyung and Deshmukh, Sachin S and Yoganarasimha, D and Savelli, Francesco and Knierim, James J (2018) Egocentric coding of external items in the lateral entorhinal cortex. In: SCIENCE, 362 (6417). 945+.

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Abstract

Episodic memory, the conscious recollection of past events, is typically experienced from a first-person (egocentric) perspective. The hippocampus plays an essential role in episodic memory and spatial cognition. Although the allocentric nature of hippocampal spatial coding is well understood, little is known about whether the hippocampus receives egocentric information about external items. We recorded in rats the activity of single neurons from the lateral entorhinal cortex (LEC) and medial entorhinal cortex (MEC), the two major inputs to the hippocampus. Many LEC neurons showed tuning for egocentric bearing of external items, whereas MEC cells tended to represent allocentric bearing. These results demonstrate a fundamental dissociation between the reference frames of LEC and MEC neural representations.

Item Type:	Journal Article
Publication:	SCIENCE
Publisher:	AMER ASSOC ADVANCEMENT SCIENCE
Additional Information:	Copyright for this article belongs to AMER ASSOC ADVANCEMENT SCIENCE
Department/Centre:	Division of Biological Sciences > Centre for Neuroscience
Date Deposited:	05 Jan 2019 14:31
Last Modified:	05 Jan 2019 14:31
URI:	http://eprints.iisc.ac.in/id/eprint/61223

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