Assessing bone mineral changes in response to vitamin D supplementation using natural variability in stable isotopes of Calcium in Urine

Rangarajan, Ravi and Mondal, Surajit and Thankachan, Prashanth and Chakrabarti, Ramananda and Kurpad, Anura (2018) Assessing bone mineral changes in response to vitamin D supplementation using natural variability in stable isotopes of Calcium in Urine. In: SCIENTIFIC REPORTS, 8 .

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Abstract

Osteoporosis is a chronic disease of public health importance, particularly in low and middle income countries. Measuring the bone mineral balance (BMB) in a non-invasive manner, and its response to different interventions, is critical to the definition of optimal strategies for its prevention and management. In this study, we demonstrate the usefulness of natural variability in calcium isotopes (delta(44)/Ca-40) of urine and the derived BMB estimates as a biomarker of bone health and its responsiveness to interventions. Vitamin D-3 is commonly used as a supplement for the prevention and treatment of osteoporosis, along with calcium supplements. We studied the effect of a short term vitamin D3 supplementation on changes in urine delta(44)/Ca-40 and the derived BMB. delta(44)/Ca-40 before and after the vitamin D3 supplementation yielded a statistically significant change (p = 0.050) with a positive delta(44)/Ca-40 enrichment. The mean derived BMB was net positive (0.04 +/- 0.05) in comparison to a net negative value for the control group (-0.03 +/- 0.01). These results indicate the potential usefulness of urinary natural delta(44)/Ca-40 and the derived BMB, which, along with bone mineral density could be used as a sensitive marker for precision in the prevention and treatment of osteoporosis.

Item Type:	Journal Article
Publication:	SCIENTIFIC REPORTS
Publisher:	NATURE PUBLISHING GROUP
Additional Information:	Copy right for this article belong to NATURE PUBLISHING GROUP
Department/Centre:	Division of Mechanical Sciences > Centre for Earth Sciences
Date Deposited:	27 Nov 2018 15:44
Last Modified:	27 Nov 2018 15:44
URI:	http://eprints.iisc.ac.in/id/eprint/61170

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