Biofunctionalized two-dimensional Ti3C2 MXenes for ultrasensitive detection of cancer biomarker

Kumar, Saurabh and Lei, Yongjiu and Alshareef, Niman H and Quevedo-Lopez, MA and Salama, Khaled N (2018) Biofunctionalized two-dimensional Ti3C2 MXenes for ultrasensitive detection of cancer biomarker. In: BIOSENSORS & BIOELECTRONICS, 121 . pp. 243-249.

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Abstract

In this work, ultrathin Ti3C2-MXene nanosheets were synthesized by minimally intensive layer delamination methods, and uniformly functionalized with aminosilane (f-Ti3C2-MXene) to provide a covalent binding for the immobilized bio-receptor (anti-CEA) for label free, ultrasensitive detection of cancer biomarker (carcinoem-bryonic antigen, CEA). The effect of different redox probes on the electrochemical behavior of f-Ti3C2-MXene was investigated and found that hexaammineruthenium (Ru(NH3)(6)](3+)) is the preferable redox probe for bio-sensing. The fabricated biofunctionalized Ti3C2-MXene exhibits a linear detection range of 0.0001-2000 ng mL(-1) with sensitivity of 37.9 mu A ng(-1) mL cm(-2) per decade. The wider linear detection range of our f-Ti3C2-MXene is not only higher than previously reported pristine 2D nanomaterials, but is even comparable to other hybrid 2D nanomaterials. We believe that this work opens a new window for development of MXene-based highly sensitive DNA, aptamer, enzyme, antibody, and cell based biosensors, and could be further used in drug delivery application.

Item Type:	Journal Article
Publication:	BIOSENSORS & BIOELECTRONICS
Publisher:	ELSEVIER ADVANCED TECHNOLOGY
Additional Information:	Copy right for this article belong to ELSEVIER ADVANCED TECHNOLOGY
Keywords:	2D nanomaterial; Ti3C2-MXene; Biosensor; Cancer biomarker
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering
Date Deposited:	12 Nov 2018 15:43
Last Modified:	12 Nov 2018 15:43
URI:	http://eprints.iisc.ac.in/id/eprint/61011

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