Ray, Bidisha and Mukherjee, Santanu (2018) Direct Catalytic Enantioselective Vinylogous Aldol Reaction of Allyl Ketones to Pyrazole-4,5-diones. In: JOURNAL OF ORGANIC CHEMISTRY, 83 (18). pp. 10871-10880.
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Official URL: http://dx.doi.org/10.1021/acs.joc.8b01566
Abstract
The first catalytic enantioselective vinylogous nucleophilic addition to pyrazole-4,5-diones is reported. Using quinine-derived bifunctional tertiary amino-amide as the catalyst, this direct aldol reaction of allyl ketones is shown to proceed exclusively in gamma- and E-selective manner to generate pyrazolone derivatives, bearing an oxygen-containing quaternary stereogenic center, in good yields with moderate to high enantioselectivities (up to 97:3 er).
| Item Type: | Journal Article |
|---|---|
| Publication: | JOURNAL OF ORGANIC CHEMISTRY |
| Publisher: | AMER CHEMICAL SOC |
| Additional Information: | Copy right for this article belong to AMER CHEMICAL SOC |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 17 Oct 2018 13:32 |
| Last Modified: | 17 Oct 2018 13:32 |
| URI: | http://eprints.iisc.ac.in/id/eprint/60899 |
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