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Recent Advances in the Organocatalytic Enantioselective Synthesis of Functionalized -Lactones

Mukherjee, Subrata and Biju, Akkattu T (2018) Recent Advances in the Organocatalytic Enantioselective Synthesis of Functionalized -Lactones. In: CHEMISTRY-AN ASIAN JOURNAL, 13 (17, SI). pp. 2333-2349.

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Official URL: https://doi.org/10.1002/asia.201800902


This Focus Review highlights recent developments in the organocatalytic enantioselective synthesis of -lactone derivatives. Owing to the importance of -lactones as a heterocyclic motif that is present in a variety of natural products and biologically active molecules, several catalytic methods have been developed for the synthesis of these compounds in their enantiomerically pure form. Organocatalytic methods that employ N-heterocyclic carbenes (NHCs), cinchona alkaloids, isothioureas, 4-dimethylaminopyridine (DMAP) derivatives, and phosphines have allowed the highly enantioselective synthesis of -lactones from cheap and readily available starting materials. Moreover, the inherent strain in the four-membered ring of -lactones has also been utilized in further synthetic transformations, thus making -lactones a versatile intermediate in organic synthesis.

Item Type: Journal Article
Additional Information: The Copyright for this article belong to John Wiley and Sons Ltd.
Keywords: alkaloids; carbenes; isothiourea; lactones; organocatalysis
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 26 Sep 2018 15:27
Last Modified: 02 Aug 2022 05:30
URI: https://eprints.iisc.ac.in/id/eprint/60735

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