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Centrosome Inheritance Does Not Regulate Cell Fate in Granule Neuron Progenitors of the Developing Cerebellum

Chatterjee, Anindo and Chinnappa, Kaviya and Ramanan, Narendrakumar and Mani, Shyamala (2018) Centrosome Inheritance Does Not Regulate Cell Fate in Granule Neuron Progenitors of the Developing Cerebellum. In: CEREBELLUM, 17 (5). pp. 685-691.

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Official URL: http://dx.doi.org/10.1007/s12311-018-0935-4


An inherent asymmetry exists between the two centrosomes of a dividing cell. One centrosome is structurally more mature (mother centrosome) than the other (daughter centrosome). Post division, one daughter cell inherits the mother centrosome while the other daughter cell inherits the daughter centrosome. Remarkably, the kind of centrosome inherited is associated with cell fate in several developmental contexts such as in radial glial progenitors in the developing mouse cortex, Drosophila neuroblast divisions and in Drosophila male germline stem cells. However, the role of centrosome inheritance in granule neuron progenitors in the developing cerebellum has not been investigated. Here, we show that mother and daughter centrosomes do exist in these progenitors, and the amount of pericentriolar material (PCM) each centrosome possesses is different. However, we failed to observe any correlation between the fate adopted by the daughter cell and the nature of centrosome it inherited.

Item Type: Journal Article
Publication: CEREBELLUM
Publisher: SPRINGER
Additional Information: Copy right for this article belong to SPRINGER, 233 SPRING ST, NEW YORK, NY 10013 USA
Keywords: Mother centrosome; Pericentriolar material (PCM); Cell fate; Cerebellar granule neuron progenitors (CGNPs)
Department/Centre: Division of Biological Sciences > Centre for Neuroscience
Date Deposited: 26 Sep 2018 15:27
Last Modified: 26 Sep 2018 15:27
URI: http://eprints.iisc.ac.in/id/eprint/60727

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