Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues

Varnava, Kyriakos Gabriel and Reynisson, Johannes and Raghothama, Srinivasrao and Sarojini, Vijayalekshmi (2018) Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues. In: PEPTIDE SCIENCE, 110 (4).

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Abstract

This work demonstrates that the human autophagy 16 polypeptide (Atg16) has antibacterial and antibiofilm potential, perturbs both Gram positive and negative bacterial membranes and subsequently also produces ROS in compromised bacteria. Engineered Atg 16 analogues containing 1- and 2-naphthyl alanines showed significant enhancement of antibacterial activity and eradicated biofilms while also possessing negligible hemolysis of mouse erythrocytes. This new family of antibacterial peptides are promising candidates in the fight against bacterial biofilms, responsible for several thousand deaths annually which are predicted to rise into the millions.

Item Type:	Journal Article
Publication:	PEPTIDE SCIENCE
Publisher:	WILEY
Additional Information:	Copy right for this article belong to WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Keywords:	antimicrobial peptide; biofilm; membrane lysis; scanning electron microscopy; transmission electron microscopy
Department/Centre:	Division of Chemical Sciences > NMR Research Centre (Formerly Sophisticated Instruments Facility)
Date Deposited:	25 Sep 2018 17:31
Last Modified:	25 Sep 2018 17:31
URI:	http://eprints.iisc.ac.in/id/eprint/60717

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