Single-particle mass spectrometry with arrays of frequency-addressed nanomechanical resonators

Sage, Eric and Sansa, Marc and Fostner, Shawn and Defoort, Martial and Gely, Marc and Naik, Akshay K and Morel, Robert and Duraffourg, Laurent and Roukes, Michael L and Alava, Thomas and Jourdan, Guillaume and Colinet, Eric and Masselon, Christophe and Brenac, Ariel and Hentz, Sebastien (2018) Single-particle mass spectrometry with arrays of frequency-addressed nanomechanical resonators. In: NATURE COMMUNICATIONS, 9 .

PDF Nat_Com_9_3283_2018.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy

Abstract

One of the main challenges to overcome to perform nanomechanical mass spectrometry analysis in a practical time frame stems from the size mismatch between the analyte beam and the small nanomechanical detector area. We report here the demonstration of mass spectrometry with arrays of 20 multiplexed nanomechanical resonators; each resonator is designed with a distinct resonance frequency which becomes its individual address. Mass spectra of metallic aggregates in the MDa range are acquired with more than one order of magnitude improvement in analysis time compared to individual resonators. A 20 NEMS array is probed in 150 ms with the same mass limit of detection as a single resonator. Spectra acquired with a conventional time-of-flight mass spectrometer in the same system show excellent agreement. We also demonstrate how mass spectrometry imaging at the single-particle level becomes possible by mapping a 4-cm-particle beam in the MDa range and above.

Item Type:	Journal Article
Publication:	NATURE COMMUNICATIONS
Publisher:	NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
Additional Information:	Copy right for this article belong to NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering
Date Deposited:	06 Sep 2018 15:43
Last Modified:	06 Sep 2018 15:43
URI:	http://eprints.iisc.ac.in/id/eprint/60584

Actions (login required)

View Item