Sunkari, Yashoda Krishna and Pulukuri, Kiran Kumar and Kandiyal, Pancham Singh and Vaishnav, Jayanti and Ampapathi, Ravi Sankar and Chakraborty, Tushar Kanti (2018) Conformation Analysis of GalNAc-Appended Sugar Amino Acid Foldamers as Glycopeptide Mimics. In: CHEMBIOCHEM, 19 (14). pp. 1507-1513.
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Abstract
Sugar amino acid (SAA)-based foldamers with well-defined secondary structures were appended with N-acetylgalactosamine (GalNAc) sugars to access sequence-defined, multidentate glycoconjugates with full control over number, spacing and position. Conformation analysis of these glycopeptides by extensive NMR spectroscopic studies revealed that the appended GalNAc units had a profound influence on the native conformational behaviour of the SAA foldamers. Whereas the 2,5-cis glycoconjugate showed a helical structure in water, comprising of two consecutive 16-membered hydrogen bonds, its 2,5-trans congener displayed an unprecedented 16/10-mixed turn structure not seen before in any glycopeptide foldamer.
Item Type: | Journal Article |
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Publication: | CHEMBIOCHEM |
Publisher: | WILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANY |
Additional Information: | Copyright of this article belong to WILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANY |
Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
Date Deposited: | 09 Aug 2018 15:40 |
Last Modified: | 09 Aug 2018 15:40 |
URI: | http://eprints.iisc.ac.in/id/eprint/60390 |
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