Hydrogen bond surrogate stabilized water soluble 3(10)-helix from a disordered pentapeptide containing coded alpha-amino acids

Pal, Sunit and Prabhakaran, Erode N (2018) Hydrogen bond surrogate stabilized water soluble 3(10)-helix from a disordered pentapeptide containing coded alpha-amino acids. In: TETRAHEDRON LETTERS, 59 (26). pp. 2515-2519.

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Abstract

Replacing a hypothetical i + 3 -> i peptide H-bond in a disordered pentapeptide, that lacks any helicogenic C-alpha-tetrasubstituted residues, with a propyl linker and carbamylating the N-terminal nitrogen constrains it in the elusive 3(10)-helical structure with high helicity and stability under varying conditions of temperature and pH, confirmed by NMR and CD analyses. (C) 2018 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Publication:	TETRAHEDRON LETTERS
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Additional Information:	Copyright of this article belong to PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	19 Jul 2018 14:54
Last Modified:	25 Aug 2022 11:49
URI:	https://eprints.iisc.ac.in/id/eprint/60242

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