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Maneuverability of Magnetic Nanomotors Inside Living Cells

Pal, Malay and Somalwar, Neha and Singh, Anumeha and Bhat, Ramray and Eswarappa, Sandeep M and Saini, Deepak K and Ghosh, Ambarish (2018) Maneuverability of Magnetic Nanomotors Inside Living Cells. In: ADVANCED MATERIALS, 30 (22).

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Official URL: https://dx.doi.org/10.1002/adma.201800429


Spatiotemporally controlled active manipulation of external micro-/nanoprobes inside living cells can lead to development of innovative biomedical technologies and inspire fundamental studies of various biophysical phenomena. Examples include gene silencing applications, real-time mechanical mapping of the intracellular environment, studying cellular response to local stress, and many more. Here, for the first time, cellular internalization and subsequent intracellular manipulation of a system of helical nanomotors driven by small rotating magnetic fields with no adverse effect on the cellular viability are demonstrated. This remote method of fuelling and guidance limits the effect of mechanical transduction to cells containing external probes, in contrast to ultrasonically or chemically powered techniques that perturb the entire experimental volume. The investigation comprises three cell types, containing both cancerous and noncancerous types, and is aimed toward analyzing and engineering the motion of helical propellers through the crowded intracellular space. The studies provide evidence for the strong anisotropy, heterogeneity, and spatiotemporal variability of the cellular interior, and confirm the suitability of helical magnetic nanoprobes as a promising tool for future cellular investigations and applications.

Item Type: Journal Article
Additional Information: Copy right of this article belong to WILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANY
Department/Centre: Division of Biological Sciences > Biochemistry
Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Division of Electrical Sciences > Electrical Communication Engineering
Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering
Division of Physical & Mathematical Sciences > Physics
Date Deposited: 26 Jun 2018 15:59
Last Modified: 26 Jun 2018 15:59
URI: http://eprints.iisc.ac.in/id/eprint/60091

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