MiRNomics Reveals Breast Cancer Cells Cultured on 3D Scaffolds Better Mimic Tumors in Vivo than Conventional 2D Culture

Balachander, Gowri Manohari and Rajashekar, Balaji and Sarashetti, Prasad M and Rangarajan, Annapoorni and Chatterjee, Kaushik (2018) MiRNomics Reveals Breast Cancer Cells Cultured on 3D Scaffolds Better Mimic Tumors in Vivo than Conventional 2D Culture. In: ACS BIOMATERIALS SCIENCE & ENGINEERING, 4 (1). pp. 116-127.

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Abstract

Tissue-engineering-based three-dimensional (3D) models offer several advantages over conventional two-dimensional (2D) cultures and can mimic tissues in vivo. Although studies have 3D scaffolds. The changes in the expression of several known microRNAs were similar to the changes reported in highly invasive cancers and their profiles highly correlated with 3D culture better mimics the tissue in vivo with novel insights into the roles of miRNAs in modulating metastatic progression.

Item Type:	Journal Article
Publication:	ACS BIOMATERIALS SCIENCE & ENGINEERING
Publisher:	10.1021/acsbiomaterials.7b00694
Additional Information:	Copy right for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	02 Mar 2018 15:07
Last Modified:	02 Mar 2018 15:07
URI:	http://eprints.iisc.ac.in/id/eprint/58885

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