Novel thyroid hormone analogues, enzyme inhibitors and mimetics, and their action

Mondal, Santanu and Mugesh, Govindasamy (2017) Novel thyroid hormone analogues, enzyme inhibitors and mimetics, and their action. In: MOLECULAR AND CELLULAR ENDOCRINOLOGY, 458 (C, SI). pp. 91-104.

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Abstract

Thyroid hormones (THs) play key roles in modulating the overall metabolism of the body, protein synthesis, fat metabolism, neuronal and bone growth, and cardiovascular as well as renal functions. In this review, we discuss on the thyroid hormone synthesis and activation, thyroid hormone receptors (TRs) and mechanism of action, applications of thyroid hormone analogues, particularly the compounds that are selective ligands for TR beta receptors, or enzyme inhibitors for the treatment of thyroidal disorders with a specific focus on thyroid peroxidase and iodothyronine deiodinases. We also discuss on the development of small-molecule deiodinase mimetics and their mechanism of deiodination, as these compounds have the potential to regulate the thyroid hormone levels. (C) 2017 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Publication:	MOLECULAR AND CELLULAR ENDOCRINOLOGY
Publisher:	10.1016/j.mce.2017.04.006
Additional Information:	Copy right for this article belongs to the ELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	20 Jan 2018 06:19
Last Modified:	20 Jan 2018 06:19
URI:	http://eprints.iisc.ac.in/id/eprint/58829

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