Opsin3-A Link to Visible Light-Induced Skin Pigmentation

Setty, Subba Rao Gangi (2018) Opsin3-A Link to Visible Light-Induced Skin Pigmentation. In: JOURNAL OF INVESTIGATIVE DERMATOLOGY, 138 (1). pp. 13-15.

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Abstract

Skin pigmentation is primarily dependent on melanogenesis, a physiological process that occurs in melanosomes of melanocytes. Solar radiation modulates pigmentation through variety of signaling pathways, but the mechanism of visible light-induced hyperpigmentation remains uncharacterized. Passeron's group recently reported that visible light stimulates opsin3-regulated calcium-dependent microphthalmia-associated transcription factor activation that increases pigment gene expression and that it also causes the clustering of melanogenic enzymes. Together, these processes possibly contribute to long-lasting hyperpigmentation in the melanocompetent skins.

Item Type:	Editorials/Short Communications
Publication:	JOURNAL OF INVESTIGATIVE DERMATOLOGY
Publisher:	10.1016/j.jid.2017.09.025
Additional Information:	Copy right for this article belongs to the ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	20 Jan 2018 06:31
Last Modified:	20 Jan 2018 06:31
URI:	http://eprints.iisc.ac.in/id/eprint/58818

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