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Hepatitis C virus: Enslavement of host factors

Sharma, Geetika and Raheja, Harsha and Das, Saumitra (2018) Hepatitis C virus: Enslavement of host factors. In: IUBMB LIFE, 70 (1). pp. 41-49.

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Official URL: http://dx.doi.org/10.1002/iub.1702


Hepatitis C virus (HCV) has infected over 170 million people world-wide. This infection causes severe liver damage that can progress to hepatocellular carcinoma leading to death of the infected patients. Development of a cell culture model system for the study of HCV infection in the recent past has helped the researchers world-wide to understand the biology of this virus. Studies over the past decade have revealed the tricks played by the virus to sustain itself, for as long as 40 years, in the host setup without being eliminated by the immune system. Today we understand that the host organelles and different cellular proteins are affected during HCV infection. This cytoplasmic virus has all the cellular organelles at its disposal to successfully replicate, from ribosomes and intracellular membranous structures to the nucleus. It modulates these organelles at both the structural and the functional levels. The vast knowledge about the viral genome and viral proteins has also helped in the development of drugs against the virus. Despite the achieved success rate to cure the infected patients, we struggle to eliminate the cases of recurrence and the non-responders. Such cases might emerge owing to the property of the viral genome to accumulate mutations during its succeeding replication cycles which favours its survival. The current situation calls an urgent need for alternate therapeutic strategies to counter this major problem of human health. (c) 2017 IUBMB Life, 70(1):41-49, 2018

Item Type: Journal Article
Publication: IUBMB LIFE
Publisher: 10.1002/iub.1702
Additional Information: Copy right for this article belongs to the WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 20 Jan 2018 06:33
Last Modified: 20 Jan 2018 06:33
URI: http://eprints.iisc.ac.in/id/eprint/58817

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