mRNA Traffic Control Reviewed: N6-Methyladenosine (m(6)A) Takes the Driver's Seat

Visvanathan, Abhirami and Somasundaram, Kumaravel (2018) mRNA Traffic Control Reviewed: N6-Methyladenosine (m(6)A) Takes the Driver's Seat. In: BIOESSAYS, 40 (1).

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Abstract

Messenger RNA is a flexible tool box that plays a key role in the dynamic regulation of gene expression. RNA modifications variegate the message conveyed by the mRNA. Similar to DNA and histone modifications, mRNA modifications are reversible and play a key role in the regulation of molecular events. Our understanding about the landscape of RNA modifications is still rudimentary in contrast to DNA and histone modifications. The major obstacle has been the lack of sensitive detection methods since they are non-editing events. However, with the advent of next-generation sequencing techniques, RNA modifications are being identified precisely at single nucleotide resolution. In recent years, methylation at the N6 position of adenine (m(6)A) has gained the attention of RNA biologists. The m(6)A modification has a set of writers (methylases), erasers (demethylases), and readers. Here, we provide a summary of interesting facts, conflicting findings, and recent advances in the technical and functional aspects of the m(6)A epitranscriptome.

Item Type:	Journal Article
Publication:	BIOESSAYS
Publisher:	10.1002/bies.201700093
Additional Information:	Copy right for this article belongs to the WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	12 Jan 2018 09:29
Last Modified:	12 Jan 2018 09:29
URI:	http://eprints.iisc.ac.in/id/eprint/58661

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