A small molecule for theraNOstic targeting of cancer cells

Ravikumar, Govindan and Bagheri, Meisam and Saini, Deepak Kumar and Chakrapani, Harinath (2017) A small molecule for theraNOstic targeting of cancer cells. In: CHEMICAL COMMUNICATIONS, 53 (100). pp. 13352-13355.

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Abstract

Thera/NO - a small molecule that is activated by hydrogen peroxide to generate nitric oxide (NO) and a fluorescence signal is reported. Using cancer and primary cells, we show that Thera/NO preferentially releases NO in cancer cells, which can trigger DNA damage and cell death in them. The coupled fluorescence signal facilitated tracking the NO release in living cells without collateral consumption of NO.

Item Type:	Journal Article
Publication:	CHEMICAL COMMUNICATIONS
Publisher:	10.1039/c7cc08526e
Additional Information:	Copy right for this article belongs to the Royal Society of Chemistry
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	13 Jan 2018 07:25
Last Modified:	13 Jan 2018 07:25
URI:	http://eprints.iisc.ac.in/id/eprint/58573

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