The combined effect of thermal and chemotherapy on HeLa cells using magnetically actuated smart textured fibrous system

Tiwari, Pranav and Agarwal, Sakshi and Srivastava, Sachchidanand and Jain, Shilpee (2016) The combined effect of thermal and chemotherapy on HeLa cells using magnetically actuated smart textured fibrous system. In: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 106 (1). pp. 40-51.

PDF jou_bio_mat_106-1_40-51_2018.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy

Abstract

Thermal therapy combined with chemotherapy is one of the advanced and efficient methods to eradicate cancer. In this work, we fabricated magnetically actuated smart textured (MAST) fibrous systems and studied their candidacy for cancer treatment. The polycaprolactone-Fe3O4 based MAST fibers were fabricated using electrospinning technique. These MAST fibrous systems contained carbogenic quantum dots as a tracking agent and doxorubicin hydrochloride anticancer drug. Additionally, as fabricated MAST fibrous systems were able to deliver anticancer drug and heat energy simultaneously to kill HeLa cells in a 10 min period in vitro. After treatment, the metabolic activity and morphology of HeLa cells were analyzed. In addition, the mechanism of cell death was studied using flow cytometry. Interestingly, the navigation of these systems in the fluid can be controlled with the application of gradient magnetic field. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 40-51, 2018.

Item Type:	Journal Article
Publication:	JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Publisher:	10.1002/jbm.b.33812
Additional Information:	The Copyright for this article belongs to John Wiley and Sons Inc.
Keywords:	HeLa cells; magnetic fibers; navigation; noninvasive therapy; thermal therapy
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	13 Jan 2018 07:37
Last Modified:	01 Aug 2022 04:46
URI:	https://eprints.iisc.ac.in/id/eprint/58570

Actions (login required)

View Item