Reentry via high-frequency pacing in a mathematical model for human-ventricular cardiac tissue with a localized fibrotic region

Zimik, Soling and Pandit, Rahul (2017) Reentry via high-frequency pacing in a mathematical model for human-ventricular cardiac tissue with a localized fibrotic region. In: SCIENTIFIC REPORTS, 7 .

PDF SCI_REP_7_15350_2017.pdf - Published Version Download (1MB)

Abstract

Localized heterogeneities, caused by the regional proliferation of fibroblasts, occur in mammalian hearts because of diseases like myocardial infarction. Such fibroblast clumps can become sources of pathological reentrant activities, e.g., spiral or scroll waves of electrical activation in cardiac tissue. The occurrence of reentry in cardiac tissue with heterogeneities, such as fibroblast clumps, can depend on the frequency at which the medium is paced. Therefore, it is important to study the reentry-initiating potential of such fibroblast clumps at different frequencies of pacing. We investigate the arrhythmogenic effects of fibroblast clumps at high-and low-frequency pacing. We find that reentrant waves are induced in the medium more prominently at high-frequency pacing than with low-frequency pacing. We also study the other factors that affect the potential of fibroblast clumps to induce reentry in cardiac tissue. In particular, we show that the ability of a fibroblast clump to induce reentry depends on the size of the clump, the distribution and percentage of fibroblasts in the clump, and the excitability of the medium. We study the process of reentry in two-dimensional and a three-dimensional mathematical models for cardiac tissue.

Item Type:	Journal Article
Publication:	SCIENTIFIC REPORTS
Additional Information:	Copy right for this article belongs to the NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
Department/Centre:	Division of Physical & Mathematical Sciences > Physics
Date Deposited:	01 Dec 2017 06:56
Last Modified:	01 Dec 2017 06:56
URI:	http://eprints.iisc.ac.in/id/eprint/58344

Actions (login required)

View Item