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GPCR Signaling in C. elegans and Its Implications in Immune Response

Gupta, Anjali and Singh, Varsha (2017) GPCR Signaling in C. elegans and Its Implications in Immune Response. [Book Chapter]

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Official URL: http://doi.org/10.1016/bs.ai.2017.05.002


The ability to sense environmental cues is central to the survival of living organisms. G-protein-coupled receptors ( GPCRs) are, by far, the most diverse class of sensory receptors and play an important role in surveillance. As Caenorhabditis elegans lives in soil and feeds on bacteria, it must have strategies to differentiate between nutritious vs pathogenic bacteria. In C. elegans, lacking professional immune cells, GPCRs play a very important role in defense responses, for survival against pathogens. Here, we review a rich body of research to show that C. elegans uses GPCRs in different tissues for immune surveillance, immune homeostasis, as well as behavioral responses. Nematode sensory neurons and GPCRs can sense both pathogen-associated molecules as well as damageassociated molecular patterns during infection. Both fight and flight responses, activated upon exposure to pathogens, are driven by GPCRs and trimeric G proteins in the sensory neurons.

Item Type: Book Chapter
Series.: Advances in Immunology
Publisher: ELSEVIER
Additional Information: Copy right for this article belongs to the ELSEVIER ACADEMIC PRESS INC, 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 24 Nov 2017 09:48
Last Modified: 24 Nov 2017 09:48
URI: http://eprints.iisc.ac.in/id/eprint/58325

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