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Synthesis of Amide-Linked Cyclic Dinucleotide Analogues with Pyrimidine Bases

Pal, Chandan and Chakraborty, Tushar Kanti (2017) Synthesis of Amide-Linked Cyclic Dinucleotide Analogues with Pyrimidine Bases. In: ASIAN JOURNAL OF ORGANIC CHEMISTRY, 6 (10). pp. 1421-1427.

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Official URL: http://doi.org/10.1002/ajoc.201700260


A convenient procedure has been developed for the synthesis of C-2-symmetrical cyclic dinucleotide analogues that contain all-pyrimidine bases (cytosine, uracil and thymine) with amide bonds in place of natural phosphodiester linkages, starting from commercially available d-glucose diacetonide (GDA). The Vorbruggen glycosylation of a common intermediate by using various pyrimidine bases was employed as the key step in the synthesis.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the WILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANY
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 11 Nov 2017 05:10
Last Modified: 11 Nov 2017 05:10
URI: http://eprints.iisc.ac.in/id/eprint/58207

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