Novel ruthenium azo-quinoline complexes with enhanced photonuclease activity in human cancer cells

Kaulage, Mangesh H and Maji, Basudeb and Pasadi, Sanjeev and Bhattacharya, Santanu and Muniyappa, K (2017) Novel ruthenium azo-quinoline complexes with enhanced photonuclease activity in human cancer cells. In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 139 . pp. 1016-1029.

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Abstract

Coordinatively saturated ruthenium complexes with a variable net charge are currently under intense investigation for their anticancer potential. These complexes, possessing long wavelength metal-toligand charge transfer with DNA photonuclease activity,. have shown promising cytotoxic profiles. Although most of the ruthenium complexes exhibit significant photochemotherapeutic activity, their poor entry into cells hinder their development as potential drug molecules. Here, we report the synthesis and characterization of four new ruthenium (II) azo-8-hydroxyquinoline complexes, their mode of in vitro DNA binding and antiproliferative properties against cultured human cancer cell lines. The activity of these compounds prior to photoirradiation is minimal. However, they could induce DNA photonuclease activity through the generation of reactive oxygen species upon exposure to light. The activities exhibited by these complexes were found to be more efficient (>5-fold) than cisplatin, emphasizing their therapeutic potential. Collectively, these results support the idea that ruthenium (II) azo-8-hydroxyquinoline complexes can serve as potential agents in photodynamic anticancer therapy. (C) 2017 Elsevier Masson SAS. All rights reserved.

Item Type:	Journal Article
Publication:	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Additional Information:	Copy right for this article belongs to the ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 23 RUE LINOIS, 75724 PARIS, FRANCE
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	03 Nov 2017 10:46
Last Modified:	03 Nov 2017 10:46
URI:	http://eprints.iisc.ac.in/id/eprint/58149

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