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Catalytic Enantioselective Vinylogous Allylic Alkylation of Coumarins

Kayal, Satavisha and Mukherjee, Santanu (2017) Catalytic Enantioselective Vinylogous Allylic Alkylation of Coumarins. In: ORGANIC LETTERS, 19 (18). pp. 4944-4947.

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Official URL: http://doi.org/10.1021/acs.orglett.7b02421


An unprecedented, organocatalytic enantioselective vinylogous gamma-allylic alkylation of 4-methylcoumarins has been developed. Using allylic carbonates as the allyl source, this reaction is catalyzed by Lewis basic dimeric Cinchona alkaloid (QD)(2)PHAL and proceeds exclusively in a gamma- and branched-selective manner to produce densely functionalized coumarin derivatives generally in good yields with good to high enantioselectivities (up to 97:3 er).

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 21 Oct 2017 06:18
Last Modified: 21 Oct 2017 06:18
URI: http://eprints.iisc.ac.in/id/eprint/58061

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