Structurally different mono-, bi- and trinuclear Pd(II) complexes and their DNA/protein interaction, DNA cleavage, and anti-oxidant, anti-microbial and cytotoxic studies

Shanmugapriya, A and Jain, Ruchi and Sabarinathan, D and Kalaiarasi, G and Dallemerd, F and Prabhakaran, R (2017) Structurally different mono-, bi- and trinuclear Pd(II) complexes and their DNA/protein interaction, DNA cleavage, and anti-oxidant, anti-microbial and cytotoxic studies. In: NEW JOURNAL OF CHEMISTRY, 41 (18). pp. 10324-10338.

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Abstract

A series of new structurally different Pd(II) complexes was obtained by the reactions between K-2PdCl4], 3-methoxysalicylaldehyde-4(N)-substituted thiosemicarbazone H2L1-H2L4] and bis(diphenylphosphino) ethane dppe]. All the complexes were characterized by using various spectral techniques (IR, electronic, H-1-NMR and mass spectroscopy). The crystal structures of complexes 1, 3, 4 and 3a & 4a were determined using X-ray crystallographic technique. The interactions of the new complexes with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) were evaluated using various spectroscopic methods, which showed the interaction potential of the complexes with CT-DNA and BSA. Further, they cleaved supercoiled DNA pBR322. The anti-oxidant profiles of the complexes were found to be better than the standards against 2,2'-diphenyl-1-picrylhydrazyl radicals (DPPH) and superoxide anion radicals. The antibacterial activity of the complexes against five pathogenic bacteria such as Staphylococcus aureus, Salmonella typhi, Escherichia coli, Bacillus subtilis and Pseudomonas aeruginosa was found to be better than their parent ligands. The complexes exhibited potential cytotoxicity against human breast cancer cells (MCF-7) in the following order: 4 > 3 > 1 > cisplatin > 2.

Item Type:	Journal Article
Publication:	NEW JOURNAL OF CHEMISTRY
Additional Information:	Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	21 Oct 2017 06:13
Last Modified:	21 Oct 2017 06:13
URI:	http://eprints.iisc.ac.in/id/eprint/58056

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