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Population differences in brain morphology: Need for population specific brain template

Rao, Naren P and Jeelani, Haris and Achalia, Rashmin and Achalia, Garima and Jacob, Arpitha and Bharath, Rose Dawn and Varambally, Shivarama and Venkatasubramanian, Ganesan and Yalavarthy, Phaneendra K (2017) Population differences in brain morphology: Need for population specific brain template. In: PSYCHIATRY RESEARCH-NEUROIMAGING, 265 . pp. 1-8.

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Official URL: https://doi.org/10.1016/j.pscychresns.2017.03.018


Brain templates provide a standard anatomical platform for population based morphometric assessments. Typically, standard brain templates for such assessments are created using Caucasian brains, which may not be ideal to analyze brains from other ethnicities. To effectively demonstrate this, we compared brain morphometric differences between T1 weighted structural MRI images of 27 healthy Indian and Caucasian subjects of similar age and same sex ratio. Furthermore, a population specific brain template was created from MRI images of healthy Indian subjects and compared with standard Montreal Neurological Institute (MNI-152) template. We also examined the accuracy of registration of by acquiring a different T1 weighted MRI data set and registering them to newly created Indian template and MNI-152 template. The statistical analysis indicates significant difference in global brain measures and regional brain structures of Indian and Caucasian subjects. Specifically, the global brain measurements of the Indian brain template were smaller than that of the MNI template. Also, Indian brain images were better realigned to the newly created template than to the MNI-152 template. The notable variations in Indian and Caucasian brains convey the need to build a population specific Indian brain template and atlas.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
Department/Centre: Division of Interdisciplinary Sciences > Supercomputer Education & Research Centre
Date Deposited: 29 Jul 2017 07:27
Last Modified: 29 Jul 2017 07:27
URI: http://eprints.iisc.ac.in/id/eprint/57496

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