A plant-derived dehydrorotenoid: a new inhibitor of hepatitis C virus entry

Bose, Mihika and Kamra, Mohini and Mullick, Ranajoy and Bhattacharya, Santanu and Das, Saumitra and Karande, Anjali A (2017) A plant-derived dehydrorotenoid: a new inhibitor of hepatitis C virus entry. In: FEBS LETTERS, 591 (9). pp. 1305-1317.

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Abstract

Emergence of drug-resistant viruses, high cost and adverse side-effects associated with the standard therapy against hepatitis C virus (HCV) infection demonstrate the need for development of well tolerated and effective antivirals. We identified and chemically characterised the dehydrorotenoid boeravinone H, isolated from the herb Boerhaviadiffusa, as a new inhibitor of HCV entry. The compound significantly inhibits the binding and entry of hepatitis C-like particles (HCV-LPs) in hepatoma cells invitro with no apparent cytotoxicity. Boeravinone H inhibits the initial phase of HCV entry probably by acting directly on the viral particle. Importantly, the compound prevents HCV entry and infection in cell culture (exvivo). Thus, boeravinone H is a potential antiviral agent for the prevention and control of HCV infection.

Item Type:	Journal Article
Publication:	FEBS LETTERS
Additional Information:	Copy right for this article belongs to the WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Department/Centre:	Division of Biological Sciences > Biochemistry Division of Biological Sciences > Microbiology & Cell Biology Division of Chemical Sciences > Organic Chemistry
Date Deposited:	03 Jun 2017 09:35
Last Modified:	03 Jun 2017 09:35
URI:	http://eprints.iisc.ac.in/id/eprint/57093

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