Reddy, N B Gopal and Krishna, P Murali and Kumar, S S Shantha and Patil, P Yogesh and Nethaji, Munirathinam (2017) Structure and spectroscopic investigations of a bi-dentate N `-(4-ethylphenyl)methylidene]-4-hydroxybenzohydrazide and its Co(II), Ni(II), Cu(II) and Cd(II) complexes: Insights relevant to biological properties. In: JOURNAL OF MOLECULAR STRUCTURE, 1137 . pp. 543-552.
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Abstract
The present paper describes the synthesis of novel ligand, N'-(4-ethylphenyl)methylidene]-4-hydroxy benzohydrazide (HL) and its Co(II), Ni(II), Cu(II) and Cd(II) complexes. The ligand (HL) crystallizes in orthorhombic lattice in P2(1)2(1)2(1) space group with a = 7.9941 (7) angstrom, b = 11.6154 (10) angstrom, c = 15.2278 (13) angstrom, alpha = beta = gamma = 90 degrees. Spectroscopic data gives the strong evidence that ligand is coordinated through azomethine nitrogen and enolic oxygen with metal ion. The DNA binding studies revealed that the complexes bind to CT-DNA via intercalation/electrostatic interaction. All the targeted compounds showed more pronounced DNA cleavage activity in the presence of H2O2 and also inhibit the growth of in vitro antibacterial activity against Gram-positive and Gram-negative bacteria. (C) 2017 Elsevier B.V. All rights reserved.
| Item Type: | Journal Article |
|---|---|
| Publication: | JOURNAL OF MOLECULAR STRUCTURE |
| Publisher: | ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Additional Information: | Copy right for this article belongs to the ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Department/Centre: | Division of Chemical Sciences > Inorganic & Physical Chemistry |
| Date Deposited: | 20 May 2017 05:21 |
| Last Modified: | 20 May 2017 05:21 |
| URI: | http://eprints.iisc.ac.in/id/eprint/56892 |
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