Supramolecular Gels from Conjugates of Bile Acids and Amino Acids and Their Applications

Maity, Mitasree and Maitra, Uday (2017) Supramolecular Gels from Conjugates of Bile Acids and Amino Acids and Their Applications. In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (13). pp. 1713-1720.

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Abstract

Hydrogels composed of low molecular weight molecules are gaining increasing importance in biomedical applications. In this work, we report the formation of injectable hydrogels from bile acid-amino acid conjugates. The hydrogelation ability was dependent on multiple factors such as the bile acid backbone, linkage between the bile acid and the amino acid, and pH. We have shown that the gelation properties depend on multiple noncovalent interactions and on the balance between hydrophobic and hydrophilic characteristics of the molecules. Crystal structures of lithocholyl-L-phenylalanine, lithocholylglycine, lithocholyl-L-valine, and lithocholyl-L-alanine were also determined and compared. Finally, the rigid hydrogel frameworks were utilized to produce inorganic-organic composite materials with gold and ZnO nanoparticles.

Item Type:	Journal Article
Publication:	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Publisher:	WILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANY
Additional Information:	Copy right for this article belongs to the WILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANY
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	20 May 2017 04:26
Last Modified:	20 May 2017 04:26
URI:	http://eprints.iisc.ac.in/id/eprint/56855

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