Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells

Yadavalli, S and Jayaram, S and Manda, S S and Madugundu, A K and Nayakanti, D S and Tan, T Z and Bhat, R and Rangarajan, A and Chatterjee, A and Gowda, H and Thiery, J P and Kumar, P (2017) Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells. In: SCIENTIFIC REPORTS, 7 .

PDF Sci_Rep_7_43710_2017.pdf - Published Version Download (1MB)

Abstract

Circulating tumor cells (CTCs) play a crucial role in cancer dissemination and provide a promising source of blood-based markers. Understanding the spectrum of transcriptional profiles of CTCs and their corresponding regulatory mechanisms will allow for a more robust analysis of CTC phenotypes. The current challenge in CTC research is the acquisition of useful clinical information from the multitude of high-throughput studies. To gain a deeper understanding of CTC heterogeneity and identify genes, pathways and processes that are consistently affected across tumors, we mined the literature for gene expression profiles in CTCs. Through in silico analysis and the integration of CTC-specific genes, we found highly significant biological mechanisms and regulatory processes acting in CTCs across various cancers, with a particular enrichment of the leukocyte extravasation pathway. This pathway appears to play a pivotal role in the migration of CTCs to distant metastatic sites. We find that CTCs from multiple cancers express both epithelial and mesenchymal markers in varying amounts, which is suggestive of dynamic and hybrid states along the epithelial-mesenchymal transition (EMT) spectrum. Targeting the specific molecular nodes to monitor disease and therapeutic control of CTCs in real time will likely improve the clinical management of cancer progression and metastases.

Item Type:	Journal Article
Publication:	SCIENTIFIC REPORTS
Publisher:	NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
Additional Information:	Copy right for this article belongs to the NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	03 Apr 2017 04:16
Last Modified:	03 Apr 2017 04:16
URI:	http://eprints.iisc.ac.in/id/eprint/56421

Actions (login required)

View Item