Adeyemo, Aderonke Ajibola and Shettar, Abhijith and Bhat, Imtiyaz Ahmad and Kondaiah, Paturu and Mukherjee, Partha Sarathi (2017) Self-Assembly of Discrete Ru-8(II) Molecular Cages and Their in Vitro Anticancer Activity. In: INORGANIC CHEMISTRY, 56 (1). pp. 608-617.
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Abstract
Four new octanudear Ru(II) cages (OC-1-OC-4) were synthesized from dinuclear p-cymene ruthenium(II) acceptors Ru-2(mu-eta(4)-C2O4)(CH3OH)(2)(eta(6)-p-cymene)(2)](O3SCF3)(2) (A(1)), Ru-2(mu-n(4)-C6H2O4)(CH3OH)(2)(eta(6)-p-cymene)(2)]-(O3SCF3)(2) (A(2)), RU2(dhnq) (H2O)(2) (eta(6)-p-cymene)(2)] (O3SCF3)(2) (A(3)), and Ru-2(dhtq)(H2O)(2)(eta(6)-p-cymene)(2)](O3SCF3)(2) (A4) separately with a tetradentate pyridyl ligand (L-1) in methanol using coordination-driven self-assembly L-1= N,N,N',N'-tetra(pyridin-4-yl)benzene-1,4-diamine]. The octanudear cages are fully characterized by various spectroscopic techniques including single-crystal X-ray diffraction analysis of OC-4. The self-assembled cages show strong in vitro anticancer activity against human lung adenocarcinoma A549 and human cervical cancer HeLa cell lines as observed from the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Of all the octanuclear cages, OC-3 exhibits remarkable anticancer activity against both cancer cell lines and is more active than that reported for cisplatin. The excellent anticancer activity of OC-3 and OC-4 highlights the importance of the synergistic effects of the spacer component of the dinuclear p-cymene Ru(11) acceptor clips.
Item Type: | Journal Article |
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Publication: | INORGANIC CHEMISTRY |
Additional Information: | Copy right for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA |
Department/Centre: | Division of Biological Sciences > Molecular Reproduction, Development & Genetics Division of Chemical Sciences > Inorganic & Physical Chemistry |
Date Deposited: | 10 Feb 2017 09:51 |
Last Modified: | 10 Feb 2017 09:51 |
URI: | http://eprints.iisc.ac.in/id/eprint/56214 |
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