High Antibacterial Activity of Functionalized Chemically Exfoliated MoS2

Pandit, Subhendu and Karunakaran, Subbaraj and Boda, Sunil Kumar and Basu, Bikramjit and De, Mrinmoy (2016) High Antibacterial Activity of Functionalized Chemically Exfoliated MoS2. In: ACS Applied Materials & Interfaces, 8 (46). pp. 31567-31573.

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Abstract

In view of the implications of inherent resistance of pathogenic bacteria, especially ESKAPE pathogens toward most of the commercially available antibiotics and the importance of these bacteria-induced biofilrn formation leading to chronic infection, it is important to develop new generation synthetic materials with greater efficacy toward antibacterial property. In addressing this issue, this paper reports a proof-of-principle study to evaluate the potential of functionalized two-dimensional chemically exfoliated MoS2 (ce-MoS2) toward inhibitory and bactericidal property against two representative ESKAPE pathogenic strain a Gram-positive Staphylococcus aureus (MRSA) and a Gram-negative Pseudomonas aeruginosa. More significantly, the mechanistic study establishes a different extent of oxidative stress together with rapid membrane depolarization in contact with ce-MoS2 having ligands of varied charge and hydrophobicity. The implication of our results is discussed in the light of the lack of survivability of planktonic bacteria and biofilm destruction in vitro. A comparison with widely used small molecules and other nanomaterial-based therapeutics conclusively establishes a better efficacy of 2D ce-MoS2 as a new class of antibiotics.

Item Type:	Journal Article
Publication:	ACS Applied Materials & Interfaces
Publisher:	AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Additional Information:	Copy right for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	04 Jan 2017 05:34
Last Modified:	05 Nov 2018 10:27
URI:	http://eprints.iisc.ac.in/id/eprint/55861

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