Synthesis, Crystal and Molecular Structure of Boc-Pro- \bigtriangleup Phe- Ala- \bigtriangleup Phe- Ala-OMe ; A Pentapeptide with a Novel \beta -Bend Ribbon Structure

Rajashankar, Kanagalaghatta Ramabhatta and Ramakumar, Suryanarayanarao and Mal, Tapas Kumar and Chauhan, VS (1994) Synthesis, Crystal and Molecular Structure of Boc-Pro- \bigtriangleup Phe- Ala- \bigtriangleup Phe- Ala-OMe ; A Pentapeptide with a Novel \beta -Bend Ribbon Structure. In: Angewandte Chemie International Edition in English, 33 (9). pp. 970-973.

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Abstract

\alpha, \beta -Dehydroamino acid residues (2,3-didehydroamino acid residues) are found in several naturally occurring peptides from microbial sources as well as in some proteins;[1] their presence in a peptide chain produces remarkable conformational consequences.[2] In addition, dehydropeptides show enhanced resistance to enzymatic degradation.[3] Thus, introduction of \alpha, \beta -de-hydroamino acid residues into bioactive peptide sequences has become an important tool to study structure-function relationships, and to provide analogues of peptide hormones with improved bioactivity.[4]

Item Type:	Journal Article
Publication:	Angewandte Chemie International Edition in English
Publisher:	VCH Verlagsgesellschaft mbH, Weinheim
Additional Information:	The copyright belongs to VCH Verlagsgesellschaft mbH, Weinheim.
Department/Centre:	Division of Physical & Mathematical Sciences > Physics
Date Deposited:	27 Feb 2006
Last Modified:	01 Mar 2019 07:08
URI:	http://eprints.iisc.ac.in/id/eprint/5585

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