Photophysical and Biological Studies with Organometallic Ruthenium Complexes of Selenodiazole Ligands

Mitra, Raja and Sridevi, VS and Somasundaram, Kumaravel and Samuelson, Ashoka G (2016) Photophysical and Biological Studies with Organometallic Ruthenium Complexes of Selenodiazole Ligands. In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES INDIA SECTION A-PHYSICAL SCIENCES, 86 (4, SI). pp. 511-520.

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Abstract

Substituted selenodiazoles (piazselenols) were used as ligands to synthesize organometallic ruthenium(II) piano-stool complexes using the precursors (eta(6)-cymene)RuX2 (where x = Cl, Br and I). Analytical data suggested that two (eta(6)-cymene)Ru motifs were present per ligand in the solid state. However, H-1 and Se-77 NMR in DMSO solution confirmed the dissociation of the selenodiazole ligand from the ruthenium center. Interestingly, selenodiazole with naphthalene substitutes possess excellent photophysical properties. It showed strong red fluorescence (576 nm) when excited at visible region (488 nm) and was found suitable for use as an imaging agent in HCT 116 cells. Among all ligands examined, only the nitro substituted selenodiazole showed potent anticancer activity against the A2780 cell line.

Item Type:	Journal Article
Publication:	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES INDIA SECTION A-PHYSICAL SCIENCES
Additional Information:	Copy right for this article belongs to the NATL ACAD SCIENCES INDIA, 5 LAJPATRAI RD, ALLAHABAD 211002, INDIA
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	07 Dec 2016 05:50
Last Modified:	07 Dec 2016 05:50
URI:	http://eprints.iisc.ac.in/id/eprint/55528

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