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Exploring structural features of folded peptide architectures in the construction of nanomaterials

Misra, Rajkumar and Reja, Rahi M and Narendra, Lagumaddepalli V and George, Gijo and Raghothama, Srinivasarao and Gopi, Hosahudya N (2016) Exploring structural features of folded peptide architectures in the construction of nanomaterials. In: CHEMICAL COMMUNICATIONS, 52 (61). pp. 9597-9600.

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Official URL: http://dx.doi.org/10.1039/c6cc04502b


We are reporting the influence of foldamer structures on their self-assembled architectures. In a sharp contrast to the ordered alpha, gamma-hybrid 12-helix obtained from 1 : 1 alternating Aib and gamma-Phe, the alpha, gamma-hybrid peptides constituted with alpha-Phe and 4,4-dimethyl gamma-amino acid (Aic) displayed the extended sheet type of conformations in solution and spontaneously self-assembled into thermally and proteolytically stable capsules. In contrast, the conformationally ordered 12-helix self-assembled into a three-dimensional supra-molecular polyhedron.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre: Division of Chemical Sciences > NMR Research Centre (Formerly Sophisticated Instruments Facility)
Date Deposited: 08 Oct 2016 06:50
Last Modified: 08 Oct 2016 06:50
URI: http://eprints.iisc.ac.in/id/eprint/54719

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