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Activation of the motor protein upon attachment: Anchors weigh in on cytoplasmic dynein regulation

Ananthanarayanan, Vaishnavi (2016) Activation of the motor protein upon attachment: Anchors weigh in on cytoplasmic dynein regulation. In: BIOESSAYS, 38 (6). pp. 514-525.

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Official URL: http://dx.doi.org/10.1002/bies.201600002


Cytoplasmic dynein is the major minus-end-directed motor protein in eukaryotes, and has functions ranging from organelle and vesicle transport to spindle positioning and orientation. The mode of regulation of dynein in the cell remains elusive, but a tantalising possibility is that dynein is maintained in an inhibited, non-motile state until bound to cargo. In vivo, stable attachment of dynein to the cell membrane via anchor proteins enables dynein to produce force by pulling on microtubules and serves to organise the nuclear material. Anchor proteins of dynein assume diverse structures and functions and differ in their interaction with the membrane. In yeast, the anchor protein has come to the fore as one of the key mediators of dynein activity. In other systems, much is yet to be discovered about the anchors, but future work in this area will prove invaluable in understanding dynein regulation in the cell.

Item Type: Journal Article
Publication: BIOESSAYS
Additional Information: Copy right for this article belongs to the WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 28 Oct 2016 06:38
Last Modified: 28 Oct 2016 06:38
URI: http://eprints.iisc.ac.in/id/eprint/54519

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