Sridevi, S and Vasu, KS and Sampath, S and Asokan, S and Sood, AK (2016) Optical detection of glucose and glycated hemoglobin using etched fiber Bragg gratings coated with functionalized reduced graphene oxide. In: JOURNAL OF BIOPHOTONICS, 9 (7). pp. 760-769.
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An enhanced optical detection of D-glucose and glycated hemoglobin (HbA(1c)) has been established in this study using etched fiber Bragg gratings (eFBG) coated with aminophenylboronic acid (APBA)-functionalized reduced graphene oxide (RGO). The read out, namely the shift in Bragg wavelength (Delta lambda(B)) is highly sensitive to changes that occur due to the adsorption of glucose (or HbA(1c)) molecules on the eFBG sensor coated with APBA-RGO complex through a five-membered cyclic ester bond formation between glucose and APBA molecules. A limit of detection of 1 nM is achieved with a linear range of detection from 1 nM to 10 mM in the case of D-glucose detection experiments. For HbA(1c), a linear range of detection varying from 86 nM to 0.23 mM is achieved. The observation of only 4 pm (picometer) change in Delta lambda(B) even for the 10 mM lactose solution confirms the specificity of the APBA-RGO complex coated eFBG sensors to glucose molecules.
| Item Type: | Journal Article |
|---|---|
| Publication: | JOURNAL OF BIOPHOTONICS |
| Publisher: | WILEY-V C H VERLAG GMBH |
| Additional Information: | Copy right for this article belongs to the WILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANY |
| Keywords: | Fiber Bragg grating; glucose; HbA(1c); aminophenylboronic acid; reduced graphene oxide |
| Department/Centre: | Division of Chemical Sciences > Inorganic & Physical Chemistry |
| Date Deposited: | 22 Aug 2016 09:29 |
| Last Modified: | 23 Oct 2018 07:25 |
| URI: | http://eprints.iisc.ac.in/id/eprint/54464 |
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