Magnetic nanoparticles for thermal lysis and application in cancer treatment

Das, Sumana and Javvaji, Brahmanandam and Veerla, Sarath Chandra and Mahapatra, RoyD and Oraevsky, AA and Wang , LV (2016) Magnetic nanoparticles for thermal lysis and application in cancer treatment. In: Conference on Photons Plus Ultrasound - Imaging and Sensing, FEB 14-17, 2016, San Francisco, CA.

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Abstract

Chemotherapy and radiation-therapy are conventional treatment procedure of cancer. Though radiation therapy is very common practice for cancer treatment, it has limitations including incomplete and non specific destruction. Heating characteristics of magnetic nanoparticle (MNP) is modelled using molecular dynamics simulation setup. This model would give an understanding for the treatment of cancer cell through MNP associated radiation-therapy. In this paper, alternating magnetic field driven heat generation of MNP is studied using classical molecular dynamics Temperature is measured as an ensemble average of velocity of the atoms. Temperature stabilization is achieved. Under this simulation setting with certain parameters, 45 degrees C temperature was obtained in our simulations. Simulation data would be helpful for experimental analysis to treat cancerous cell in presence of MNP under exposure to radiofrequency. The in vitro thermal characteristics of magnetite nanoparticles using magnetic coil of various frequencies (5, 7.5, 10 and 15 kHz), the saturation temperature was found at 0.5 mg/mL concentration. At frequency 50 kHz the live/dead and MTT assay was performed on magnetite nanoparticles using MC3T3 cells for 10 min duration. Low radio frequency (RF) radiation induced localized heat into the metallic nanoparticles which is clearly understood using the molecular dynamics simulation setup. Heating of nanoparticle trigger the killing of the tumor cells, acts as a local therapy, as it generates less side effects in comparison to other treatments like chemotherapy and radiation therapy.

Item Type:	Conference Proceedings
Series.:	Proceedings of SPIE
Publisher:	SPIE-INT SOC OPTICAL ENGINEERING
Additional Information:	Copyright for this article belongs to the SPIE-INT SOC OPTICAL ENGINEERING, 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
Keywords:	Magnetic nanoparticles; molecular dynamics; thermal lysis; magnetic dipole; imaging; cancer treatment
Department/Centre:	Division of Mechanical Sciences > Aerospace Engineering(Formerly Aeronautical Engineering)
Date Deposited:	25 Aug 2016 10:06
Last Modified:	25 Aug 2016 10:06
URI:	http://eprints.iisc.ac.in/id/eprint/54350

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