Emerging Role and Characterization of Immunometabolism: Relevance to HIV Pathogenesis, Serious Non-AIDS Events, and a Cure

Palmer, Clovis S and Henstridge, Darren C and Yu, Di and Singh, Amit and Balderson, Brad and Duette, Gabriel and Cherry, Catherine L and Anzinger, Joshua J and Ostrowski, Matias and Crowe, Suzanne M (2016) Emerging Role and Characterization of Immunometabolism: Relevance to HIV Pathogenesis, Serious Non-AIDS Events, and a Cure. In: JOURNAL OF IMMUNOLOGY, 196 (11). pp. 4437-4444.

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Abstract

Immune cells cycle between a resting and an activated state. Their metabolism is tightly linked to their activation status and, consequently, functions. Ag recognition induces T lymphocyte activation and proliferation and acquisition of effector functions that require and depend on cellular metabolic reprogramming. Likewise, recognition of pathogen-associated molecular patterns by monocytes and macrophages induces changes in cellular metabolism. As obligate intracellular parasites, viruses manipulate the metabolism of infected cells to meet their structural and functional requirements. For example, HIV-induced changes in immune cell metabolism and redox state are associated with CD4(+) T cell depletion, immune activation, and inflammation. In this review, we highlight how HIV modifies immunometabolism with potential implications for cure research and pathogenesis of comorbidities observed in HIV-infected patients, including those with virologic suppression. In addition, we highlight recently described key methods that can be applied to study the metabolic dysregulation of immune cells in disease states.

Item Type:	Journal Article
Publication:	JOURNAL OF IMMUNOLOGY
Publisher:	AMER ASSOC IMMUNOLOGISTS
Additional Information:	Copy right for this article belongs to the AMER ASSOC IMMUNOLOGISTS, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	08 Jul 2016 06:00
Last Modified:	08 Jul 2016 06:00
URI:	http://eprints.iisc.ac.in/id/eprint/54140

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