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Cross-talk and specificity in two-component signal transduction pathways

Agrawal, Ruchi and Sahoo, Bikash Kumar and Saini, Deepak Kumar (2016) Cross-talk and specificity in two-component signal transduction pathways. In: FUTURE MICROBIOLOGY, 11 (5). pp. 685-697.

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Official URL: http://dx.doi.org/10.2217/fmb-2016-0001


Two-component signaling systems (TCSs) are composed of two proteins, sensor kinases and response regulators, which can cross-talk and integrate information between them by virtue of high-sequence conservation and modular nature, to generate concerted and diversified responses. However, TCSs have been shown to be insulated, to facilitate linear signal transmission and response generation. Here, we discuss various mechanisms that confer specificity or cross-talk among TCSs. The presented models are supported with evidence that indicate the physiological significance of the observed TCS signaling architecture. Overall, we propose that the signaling topology of any TCSs cannot be predicted using obvious sequence or structural rules, as TCS signaling is regulated by multiple factors, including spatial and temporal distribution of the participating proteins.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the FUTURE MEDICINE LTD, UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND
Keywords: cross-talk; response regulator; sensor kinase; specificity; two-component signaling
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 16 Jun 2016 07:41
Last Modified: 06 Oct 2018 13:00
URI: http://eprints.iisc.ac.in/id/eprint/54016

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