A hollow stainless steel microneedle array to deliver insulin to a diabetic rat

Vinayakumar, KB and Kulkarni, Prachit G and Nayak, MM and Dinesh, NS and Hegde, Gopalkrishna M and Ramachandra, SG and Rajanna, K (2016) A hollow stainless steel microneedle array to deliver insulin to a diabetic rat. In: JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 26 (6).

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Abstract

A novel fabrication process has been described for the development of a hollow stainless steel microneedle array using femto second laser micromachining. Using this method, a complicated microstructure can be fabricated in a single process step without using masks. The mechanical stability of the fabricated microneedle array was measured for axial and transverse loading. Skin histology was carried out to study the microneedle penetration into the rat skin. Fluid flow through the microneedle array was studied for different inlet pressures. The packaging of the microneedle array, to protect the microneedle bore blockage from dust and other atmospheric contaminations, was also considered. Finally, the microneedle array was tested and studied in vivo for insulin delivery to a diabetic rat. The results obtained were compared with the standard subcutaneous delivery with the same dose rate and were found to be in good agreement.

Item Type:	Journal Article
Publication:	JOURNAL OF MICROMECHANICS AND MICROENGINEERING
Publisher:	IOP PUBLISHING LTD
Additional Information:	Copy right for this article belongs to the IOP PUBLISHING LTD, TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
Keywords:	microneedles; insulin delivery; stainless steel; drug delivery
Department/Centre:	Division of Electrical Sciences > Electronic Systems Engineering (Formerly Centre for Electronic Design & Technology)
Date Deposited:	16 Jun 2016 07:45
Last Modified:	16 Jun 2016 07:45
URI:	http://eprints.iisc.ac.in/id/eprint/53996

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