Can we exchange water in a hydrate structure: a case study of etoricoxib

Mittapalli, Sudhir and Bolla, Geetha and Perumalla, Sravankumar and Nangia, Ashwini (2016) Can we exchange water in a hydrate structure: a case study of etoricoxib. In: CRYSTENGCOMM, 18 (16). pp. 2825-2829.

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Abstract

Novel crystalline forms of etoricoxib (ETR) with pharmaceutically acceptable coformers (generally regarded as safe, GRAS), such as glutaric acid (1 : 1), adipic acid (2 : 1), suberic acid (1 : 1), and caprolactam, were co-crystallized. The solid forms were prepared from ETR hemihydrate form I and characterized by powder XRD, DSC, and IR, and finally confirmed by single crystal X-ray diffraction. The exchange of water with an organic acid coformer in the crystal structure is explained by lattice energy calculations.

Item Type:	Journal Article
Publication:	CRYSTENGCOMM
Publisher:	ROYAL SOC CHEMISTRY
Additional Information:	Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	11 Jun 2016 09:55
Last Modified:	11 Jun 2016 09:55
URI:	http://eprints.iisc.ac.in/id/eprint/53932

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