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Dual role of arginine metabolism in establishing pathogenesis

Gogoi, Mayuri and Datey, Akshay and Wilson, Keith T and Chakravortty, Dipshikha (2016) Dual role of arginine metabolism in establishing pathogenesis. In: CURRENT OPINION IN MICROBIOLOGY, 29 . pp. 43-48.

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Official URL: http://dx.doi.org/10.1016/j.mib.2015.10.005


Arginine is an integral part of host defense when invading pathogens are encountered. The arginine metabolite nitric oxide (NO) confers antimicrobial properties, whereas the metabolite ornithine is utilized for polyamine synthesis. Polyamines are crucial to tissue repair and anti-inflammatory responses. iNOS/arginase balance can determine Th1/Th2 response. Furthermore, the host arginine pool and its metabolites are utilized as energy sources by various pathogens. Apart from its role as an immune modulator, recent studies have also highlighted the therapeutic effects of arginine. This article sheds light upon the roles of arginine metabolism during pathological conditions and its therapeutic potential.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 06 Apr 2016 07:33
Last Modified: 06 Apr 2016 07:33
URI: http://eprints.iisc.ac.in/id/eprint/53631

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