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Thermal co-reduction approach to vary size of silver nanoparticle: its microbial and cellular toxicology

Dasgupta, Nandita and Ranjan, Shivendu and Rajendran, Bhavapriya and Manickam, Venkatraman and Ramalingam, Chidambaram and Avadhani, GS and Kumar, Ashutosh (2016) Thermal co-reduction approach to vary size of silver nanoparticle: its microbial and cellular toxicology. In: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 23 (5). pp. 4149-4163.

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Official URL: http://dx.doi.org/10.1007/s11356-015-4570-z


In recent years, silver nanoparticles (AgNPs) have attracted considerable interest in the field of food, agriculture and pharmaceuticals mainly due to its antibacterial activity. AgNPs have also been reported to possess toxic behavior. The toxicological behavior of nanomaterials largely depends on its size and shape which ultimately depend on synthetic protocol. A systematic and detailed analysis for size variation of AgNP by thermal co-reduction approach and its efficacy toward microbial and cellular toxicological behavior is presented here. With the focus to explore the size-dependent toxicological variation, two different-sized NPs have been synthesized, i.e., 60 nm (Ag60) and 85 nm (Ag85). A detailed microbial toxicological evaluation has been performed by analyzing minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), diameter of inhibition zone (DIZ), growth kinetics (GrK), and death kinetics (DeK). Comparative cytotoxicological behavior was analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. It has been concluded by this study that the size of AgNPs can be varied, by varying the concentration of reactants and temperature called as ``thermal co-reduction'' approach, which is one of the suitable approaches to meet the same. Also, the smaller AgNP has shown more microbial and cellular toxicity.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the SPRINGER HEIDELBERG, TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
Keywords: Nanoparticle; Size variation; Thermal co-reduction; Characterization; Microbial toxicology; Cytotoxicology
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 02 Apr 2016 06:03
Last Modified: 25 Feb 2019 05:39
URI: http://eprints.iisc.ac.in/id/eprint/53583

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