Biochemical and Behavioral Evaluation of Human MAPT Mutations in Transgenic Drosophila melanogaster

Haddadi, Mohammad and Nongthomba, Upendra and Ramesh, SR (2016) Biochemical and Behavioral Evaluation of Human MAPT Mutations in Transgenic Drosophila melanogaster. In: BIOCHEMICAL GENETICS, 54 (1). pp. 61-72.

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Abstract

Mutations in the human microtubule-associated protein tau (hMAPT) gene including R406W and V337M result in autosomal dominant neurodegenerative disorder. These mutations lead to hyperphosphorylation and aggregation of Tau protein which is a known genetic factor underlying development of Alzheimer's disease (AD). In the present study, transgenic Drosophila models of AD expressing wild-type and mutant forms of hMAPT exhibit a progressive neurodegeneration which was manifested in the form of early death and impairment of cognitive ability. Moreover, they were also found to have significantly decreased activity of neurotransmitter enzymes accompanied by decreased cellular endogenous antioxidant profile. The extent of neurodegeneration, memory impairment, and biochemical profiles was different in the tau transgenic strains which indicate multiple molecular and cellular responses underlie each particular form of hMAPT.

Item Type:	Journal Article
Publication:	BIOCHEMICAL GENETICS
Publisher:	SPRINGER/PLENUM PUBLISHERS
Additional Information:	Copy right for this article belongs to the SPRINGER/PLENUM PUBLISHERS, 233 SPRING ST, NEW YORK, NY 10013 USA
Keywords:	hMAPT; Neurodegeneration; Memory impairment; Oxidative stress
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited:	02 Apr 2016 07:12
Last Modified:	02 Apr 2016 07:12
URI:	http://eprints.iisc.ac.in/id/eprint/53555

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