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High-throughput miniaturized microfluidic microscopy with radially parallelized channel geometry

Jagannadh, Veerendra Kalyan and Bhat, Bindu Prabhath and Julius, Lourdes Albina Nirupa and Gorthi, Sai Siva (2016) High-throughput miniaturized microfluidic microscopy with radially parallelized channel geometry. In: ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 408 (7). pp. 1909-1916.

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Official URL: http://dx.doi.org/10.1007/s00216-015-9301-2


In this article, we present a novel approach to throughput enhancement in miniaturized microfluidic microscopy systems. Using the presented approach, we demonstrate an inexpensive yet high-throughput analytical instrument. Using the high-throughput analytical instrument, we have been able to achieve about 125,880 cells per minute (more than one hundred and twenty five thousand cells per minute), even while employing cost-effective low frame rate cameras (120 fps). The throughput achieved here is a notable progression in the field of diagnostics as it enables rapid quantitative testing and analysis. We demonstrate the applicability of the instrument to point-of-care diagnostics, by performing blood cell counting. We report a comparative analysis between the counts (in cells per mu l) obtained from our instrument, with that of a commercially available hematology analyzer.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the SPRINGER HEIDELBERG, TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
Keywords: High throughput screening; Clinical / biomedical analysis; Microfluidic biosensors
Department/Centre: Division of Physical & Mathematical Sciences > Instrumentation Appiled Physics
Division of Physical & Mathematical Sciences > Physics
Date Deposited: 02 Apr 2016 09:16
Last Modified: 02 Apr 2016 09:16
URI: http://eprints.iisc.ac.in/id/eprint/53538

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