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The legacy of G. N. Ramachandran and the development of structural biology in India

Vijayan, M (2016) The legacy of G. N. Ramachandran and the development of structural biology in India. In: CURRENT SCIENCE, 110 (4). pp. 535-542.

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G. N. Ramachandran is among the founding fathers of structural molecular biology. He made pioneering contributions in computational biology, modelling and what we now call bioinformatics. The triple helical coiled coil structure of collagen proposed by him forms the basis of much of collagen research at the molecular level. The Ramachandran map remains the simplest descriptor and tool for validation of protein structures. He has left his imprint on almost all aspects of biomolecular conformation. His contributions in the area of theoretical crystallography have been outstanding. His legacy has provided inspiration for the further development of structural biology in India. After a pause, computational biology and bioinformatics are in a resurgent phase. One of the two schools established by Ramachandran pioneered the development of macromolecular crystallography, which has now grown into an important component of modern biological research in India. Macromolecular NMR studies in the country are presently gathering momentum. Structural biology in India is now poised to again approach heights of the kind that Ramachandran conquered more than a generation ago.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the INDIAN ACAD SCIENCES, C V RAMAN AVENUE, SADASHIVANAGAR, P B #8005, BANGALORE 560 080, INDIA
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 02 Apr 2016 11:20
Last Modified: 02 Apr 2016 11:20
URI: http://eprints.iisc.ac.in/id/eprint/53460

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